Hoch-Ligeti C, Harris P N, Stewart H L
J Natl Cancer Inst. 1983 Jul;71(1):211-6.
Endocardial tumors were induced in 18 rats treated with derivatives of carbamates and in 4 rats treated with derivatives of fluorenylacetamide. The endocardial tumor of 1 rat treated with N,N'-2,7-fluorenylenebisacetamide metastasized to the lung. This is the first report of metastasis of an endocardial tumor. Among the more than 60,000 accessions at the Registry of Experimental Cancers, Division of Cancer Cause and Prevention, National Cancer Institute, there are 4 untreated rats with endocardial tumors. On the basis of the light microscopic morphology, we have classified these endocardial tumors as mesenchymal.
用氨基甲酸盐衍生物处理的18只大鼠和用芴基乙酰胺衍生物处理的4只大鼠诱发了心内膜肿瘤。用N，N'-2，7-芴撑双乙酰胺处理的1只大鼠的心内膜肿瘤转移到了肺部。这是心内膜肿瘤转移的首次报道。在国家癌症研究所癌症病因与预防司实验癌症登记处的60000多份记录中，有4只未经处理的大鼠患有心内膜肿瘤。根据光学显微镜形态学，我们将这些心内膜肿瘤归类为间充质肿瘤。
