McGinnis M R, Walker D H, Folds J D
Arch Pathol Lab Med. 1980 Jun;104(6):290-2.
In a patient with chronic granulomatous disease of childhood documented by the nitroblue tetrazolium test, an infection of the mediastinal lymph nodes developed that was caused by Hansenula polymorpha, an ascomycetous yeast. To our knowledge, this yeast has not been previously shown to be an etiologic agent of disease in man. The diagnosis was made by growing the yeast from cultures of several biopsy specimens collected at the time of thoracotomy. Susceptibility testing showed that the yeast was sensitive to amphotericin B. Treatment with amphotericin B reversed this life-threatening episode.
一名经硝基蓝四氮唑试验确诊为儿童慢性肉芽肿病的患者，发生了由多形汉逊酵母（一种子囊酵母菌）引起的纵隔淋巴结感染。据我们所知，此前尚未证明这种酵母菌是人类疾病的病原体。通过在开胸手术时采集的多个活检标本培养出该酵母菌而做出诊断。药敏试验表明该酵母菌对两性霉素B敏感。用两性霉素B治疗扭转了这一危及生命的病情。
