Crowther A G
J Int Med Res. 1978;6(4):348-50. doi: 10.1177/030006057800600414.
This small study was carried out to assess the effectiveness of lactulose syrup (Duphalac) in the management of constipation in forty-six patients with terminal illnesses. The daily dose of lactulose was titrated to meet the individual patients requirements and was found to be in the region of 20 to 30 mls twice daily, despite the almost universal administration of opiates as analgesics. The study lasted 21 days in each patient capable of completing the assessment. Constipation was relieved within a an average of 3 to 4 days, and of the 512 days observed, there were 203 days in which a bowel movement occurred. Of these motions 71% were recorded as easy to move, rather than hard (21%) of loose (8%). Faecal incontinence and nausea attributable to lactulose treatment were extremely rare. Therefore, lactulose appeared to be a useful treatment for constipation in the terminally ill patient.
这项小型研究旨在评估乳果糖糖浆（杜秘克）对46例晚期疾病患者便秘的治疗效果。尽管几乎所有患者都使用了阿片类药物作为镇痛药，但乳果糖的每日剂量仍根据个体需求进行滴定，结果发现每日两次，每次剂量在20至30毫升左右。该研究对每位能够完成评估的患者持续进行21天。便秘平均在3至4天内得到缓解，在观察的512天中，有203天出现了排便。其中71%的排便记录为易于排出，而非硬便（21%）或稀便（8%）。乳果糖治疗引起的大便失禁和恶心极为罕见。因此，乳果糖似乎是治疗晚期患者便秘的有效方法。
