慢性便秘治疗期间及治疗后“杜秘克”与“刺激性”泻药的比较：一项初步研究

Comparison of "Duphalac" and "irritant" laxatives during and after treatment of chronic constipation: a preliminary study.

作者信息

Connolly P, Hughes I W, Ryan G

出版信息

Curr Med Res Opin. 1974;2(10):620-5. doi: 10.1185/03007997409111873.

Abstract

A multi-centre trial was carried out to compare the effectiveness in the treatment of chronic constipation of a lactulose preparation ("Duphalac") and "irritant" laxatives containing senna, anthraquinone derivatives or bisacodyl. The results, in 164 patients, indicate that the lactulose prepartion was more effective than the "irritant" laxatives. By Day 7, 58% of the lactulose-treated group were passing a normal stool whereas only 42% of the patients receiving an "irritant" laxative did so at the same stage in treatment. The lactulose preparation was shown to have a persistent CARRY-OVER" EFFECT, AND THIS EFFECT WAS SEEN IN SIGNIFICANTLY MORE PATIENTS RECEIVING "Duphalac" than in the "irritant" laxative group.

摘要

开展了一项多中心试验，以比较一种乳果糖制剂（“杜秘克”）与含有番泻叶、蒽醌衍生物或比沙可啶的“刺激性”泻药在治疗慢性便秘方面的效果。164名患者的试验结果表明，乳果糖制剂比“刺激性”泻药更有效。到第7天，接受乳果糖治疗的患者中有58%排出正常大便，而接受“刺激性”泻药治疗的患者在治疗的同一阶段只有42%做到了这一点。结果显示，乳果糖制剂具有持续的“延续”效应，接受“杜秘克”治疗的患者出现这种效应的人数显著多于“刺激性”泻药组。