Yamaura A, Nakamura T, Makino H, Hagihara Y
Eur Neurol. 1980;19(2):77-84. doi: 10.1159/000115131.
Among the reported complications of the antifibrinolytic therapy in the treatment of ruptured intracranial aneurysms, nausea and vomiting, cerebral arteriopathy and secondary hydrocephalus would be a matter of concern in its possible CNS involvement. However, little is known about the possibility of direct cerebral effect in synthetic antifibrinolytics. A simply designed animal experiment disclosed remarkable effects on electroencephalography, blood flow of the cerebral cortex and intracranial pressure. Such antifibrinolytics should not be given intrathecally in any situation even if the accumulation of the agents in cerebrospinal fluid is essential to prevent recurrent hemorrhage.
在报道的抗纤维蛋白溶解疗法治疗破裂颅内动脉瘤的并发症中，恶心、呕吐、脑动脉病变和继发性脑积水因其可能累及中枢神经系统而备受关注。然而，关于合成抗纤维蛋白溶解剂对大脑的直接影响可能性知之甚少。一项设计简单的动物实验揭示了其对脑电图、大脑皮质血流和颅内压有显著影响。即使这些药物在脑脊液中的蓄积对于预防再出血至关重要，在任何情况下都不应鞘内给予此类抗纤维蛋白溶解剂。
