分泌型免疫球蛋白A是兔肺表面活性物质的一个组成部分。

Secretory IgA is a component of rabbit lung surfactant.

作者信息

Paciga J E, Shelley S A, Balis J U

出版信息

Biochim Biophys Acta. 1980 Sep 1;631(3):487-94. doi: 10.1016/0304-4165(80)90024-0.

Abstract

Secretory IgA is a major protein component of rabbit lung surfactant purified by NaBr density gradient centrifugation from endobronchial lavage and minced lung tissue. Secretory IgA was found in both surfactant and non-surfactant fractions obtained from endobronchial lung washings. By contrast in minced-lung washings, which are not contaminated with proteins from the upper respiratory tree, secretory IgA is prominent only in the surfactant fraction. These findings indicate that in rabbit lung secretory IgA is present in the alveoli and is intimately associated with the surfactant system.

摘要

分泌型免疫球蛋白A是通过从支气管灌洗和切碎的肺组织中进行溴化钠密度梯度离心纯化得到的兔肺表面活性剂的主要蛋白质成分。在从支气管肺灌洗中获得的表面活性剂和非表面活性剂组分中均发现了分泌型免疫球蛋白A。相比之下，在未被上呼吸道树的蛋白质污染的切碎肺灌洗物中，分泌型免疫球蛋白A仅在表面活性剂组分中显著。这些发现表明，在兔肺中，分泌型免疫球蛋白A存在于肺泡中，并与表面活性剂系统密切相关。