Hosono M, Cinader B
Int Arch Allergy Appl Immunol. 1977;54(4):289-99. doi: 10.1159/000231840.
SJL mice became resistant to tolerance induction between the 2nd and 6th week of life. The effect on tolerance induction of radioresistant accessory (A) cells does not depend on the age of the donor, i.e. is the same whether the A-cell donor is 3 or 12 weeks old. In the thymectomized recipient, reconstituted with spleen cells of 12-week-old donors, resistance to tolerance is greater than in the corresponding intact animal. Resistance to tolerance is due to a change in the T cells, occurs at a different rate in the T cells of thymus and spleen, and my be due to change in the relative proportion of different T-cell subpopulations.
SJL小鼠在出生后第2至6周之间变得对耐受性诱导具有抗性。抗辐射辅助（A）细胞对耐受性诱导的影响不取决于供体的年龄，即无论A细胞供体是3周龄还是12周龄，其影响都是相同的。在接受胸腺切除的受体中，用12周龄供体的脾细胞进行重建后，对耐受性的抗性比相应的完整动物更强。对耐受性的抗性是由于T细胞发生了变化，在胸腺和脾脏的T细胞中以不同的速率发生，并且可能是由于不同T细胞亚群的相对比例发生了变化。
