新型降血脂化合物KC - 9432对大鼠高密度脂蛋白胆固醇的影响。

Effect of KC-9432, a new hypolipidemic compound, on high density lipoprotein cholesterol in rats.

作者信息

Seri K, Sato R, Hamazaki Y, Yamamoto T, Ishiyama N

出版信息

Atherosclerosis. 1980 Sep;37(1):97-102. doi: 10.1016/0021-9150(80)90097-0.

Abstract

KC-9432 (a new hypolipidemic compound, alpha-[p-(p-chlorobenzoyl) phenoxy-alpha-cyclohexyl acetic acid ethyl ester) was studied in rats for its effect on plasma lipid and lipoprotein levels. KC-9432 was particularly effective in hyperlipidemia in rats fed with a diet containing 2% cholesterol and 1% sodium cholate. The hypocholesterolemic activity of KC-9432 was far more potent than that of clofibrate. KC-9432 markedly increased the reduced HDL cholesterol level in dietary-induced hyperlipidemia in rats.

摘要

对KC - 9432（一种新型降血脂化合物，α-[对-（对氯苯甲酰基）苯氧基-α-环己基乙酸乙酯]）在大鼠中进行了研究，以观察其对血浆脂质和脂蛋白水平的影响。在喂食含2%胆固醇和1%胆酸钠饮食的大鼠中，KC - 9432对高脂血症特别有效。KC - 9432的降胆固醇活性远比氯贝丁酯强。KC - 9432显著提高了饮食诱导的大鼠高脂血症中降低的高密度脂蛋白胆固醇水平。