Taylor W A, Sheldon D
Int Arch Allergy Appl Immunol. 1977;54(4):322-8. doi: 10.1159/000231844.
Isoprenaline, disodium cromoglycate and PGE1 poorly inhibit antigen-induced degranulation of sensitised rat peritoneal mast cells, but in the presence of chopped rat lung their inhibitory activities were markedly enhanced. The chopped lung preparation had no effect on degranulation in the absence of an inhibitor and did not enhance the weak inhibitory potency of theophylline. Lung tissue suspensions pretreated with isoprenaline released a factor into the supernatant which enhanced the action of isoprenaline on peritoneal mast cells. The activity of this supernatant factor was destroyed by boiling for 5 min. Supernatant fluid from untreated lung tissue did not itself reduced antigen-induced degranulation or enhance the inhibitory potency of isoprenaline.
异丙肾上腺素、色甘酸钠和前列腺素E1对致敏大鼠腹膜肥大细胞抗原诱导的脱颗粒作用抑制较弱，但在加入切碎的大鼠肺组织后，它们的抑制活性显著增强。在没有抑制剂的情况下，切碎的肺组织制剂对脱颗粒没有影响，也不会增强茶碱微弱的抑制效力。用异丙肾上腺素预处理的肺组织悬液向上清液中释放了一种因子，该因子增强了异丙肾上腺素对腹膜肥大细胞的作用。该上清液因子的活性经煮沸5分钟后被破坏。未经处理的肺组织的上清液本身既不能减少抗原诱导的脱颗粒，也不能增强异丙肾上腺素的抑制效力。
