抗坏血酸与色甘酸钠在某些实验性过敏反应模型中的比较研究。
Comparative study of ascorbic acid and disodium cromoglycate in some models of experimental anaphylaxis.
作者信息
González R G, García M, Pérez Saad H, de la Vega A R
出版信息
Allergol Immunopathol (Madr). 1979 May-Jun;7(3):211-6.
PMID:89807
Abstract
The pharmacological activity of vitamin C and the antiallergic drug disodium cromoglycate are compared in models of rat mast cell degranulation and histamine release, and in protracted anaphylactic shock in the guinea pig. Our results demonstrate that ascorbic acid has a very weak inhibitory effect on degranulation and histamine release from mast cells, and therefore cannot be considered a prophylactic antiallergic drug such as disodium cromoglycate.
摘要
在大鼠肥大细胞脱颗粒和组胺释放模型以及豚鼠的迟发性过敏性休克模型中，对维生素C和抗过敏药物色甘酸钠的药理活性进行了比较。我们的结果表明，抗坏血酸对肥大细胞的脱颗粒和组胺释放具有非常微弱的抑制作用，因此不能被视为像色甘酸钠那样的预防性抗过敏药物。
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