Amino N, Yuasa T, Yabu Y, Miyai K, Kumahara Y
J Clin Endocrinol Metab. 1980 Dec;51(6):1232-4. doi: 10.1210/jcem-51-6-1232.
Protrusion of the eyes of patients with autoimmune thyroid disease was compared with that of healthy subjects. The mean values for protrusion in patients with thyrotoxic Graves' disease and Hashimoto's disease and in healthy subjects were 16.6 +/- 2.1 mm (mean +/- SD; n = 122), 14.2 +/- 1.8 mm (n = 100), and 13.9 +/- 1.9 mm (n = 558), respectively. The value of Graves' disease was significantly different from that for healthy subjects (P < 0.001). Individual values for protrusion showed a similar normal distribution in these three groups, but were displaced to higher values as a whole in Graves' disease. These results, which suggest that almost all patients with Graves' disease have exophthalmos, do not support the idea that Graves' ophthalmopathy is a distinct single autoimmune disease.
将自身免疫性甲状腺疾病患者的眼球突出情况与健康受试者进行了比较。甲状腺毒症性格雷夫斯病和桥本氏病患者以及健康受试者的眼球突出平均值分别为16.6±2.1毫米（平均值±标准差；n = 122）、14.2±1.8毫米（n = 100）和13.9±1.9毫米（n = 558）。格雷夫斯病的值与健康受试者的值有显著差异（P < 0.001）。这三组中眼球突出的个体值显示出相似的正态分布，但在格雷夫斯病中整体上向更高值偏移。这些结果表明几乎所有格雷夫斯病患者都有眼球突出，不支持格雷夫斯眼病是一种独特的单一自身免疫性疾病的观点。
