Inada M, Nishikawa M, Naito K, Ishii H, Tanaka K, Mashio Y, Imura H
Endocrinol Jpn. 1981 Aug;28(4):515-9. doi: 10.1507/endocrj1954.28.515.
In order to evaluate the effect of sex and age on the protrusion of the eyes in patients with Graves' disease, exophalmometry was performed on 95 patients, aged 16-73. The mean (+/- SE) protrusion in the 190 eyes was 17.5 +/- 0.2 mm, being significantly higher than those in normal subjects (14.9 +/- 0.2 mm) and patients with Hashimoto's disease (14.3 +/- 0.2 mm). No significant difference existed in the degree of protrusion between thyrotoxic Graves' disease patients and those maintained in an euthyroid state during treatment with antithyroid drugs. When compared in terms of the duration of the treatment, the protrusion became prominent with the increased duration of the treatment, especially in male patients, although statistically not significant. The protrusion in male patients tended to increase, though not significantly, with increasing age, whereas it decreased significantly with increasing age in female patients.
为了评估性别和年龄对格雷夫斯病患者眼球突出的影响，对95名年龄在16至73岁的患者进行了眼球突出度测量。190只眼睛的平均（±标准误）突出度为17.5±0.2毫米，显著高于正常受试者（14.9±0.2毫米）和桥本氏病患者（14.3±0.2毫米）。甲状腺毒症性格雷夫斯病患者与接受抗甲状腺药物治疗维持在甲状腺功能正常状态的患者之间，突出程度无显著差异。就治疗持续时间而言，尽管在统计学上不显著，但随着治疗持续时间的增加，突出变得明显，尤其是男性患者。男性患者的突出度虽不显著，但有随年龄增加而增加的趋势，而女性患者的突出度则随年龄增加而显著降低。
