一种来自棘阿米巴原虫的肌动蛋白结合蛋白可调节肌动蛋白丝的聚合及相互作用。
An actin-binding protein from Acanthamoeba regulates actin filament polymerization and interactions.
作者信息
Isenberg G, Aebi U, Pollard T D
出版信息
Nature. 1980 Dec 4;288(5790):455-9. doi: 10.1038/288455a0.
DOI:10.1038/288455a0
PMID:6893736
Abstract
A protein has been purified from Acanthamoeba which, like cytochalasin B, caps the end of actin filaments normally favoured for monomer addition and inhibits the interactions of actin filaments. In addition, this 'capping' protein nucleates the polymerization of actin monomers and blocks the annealing of actin filament fragments.
摘要
已从棘阿米巴中纯化出一种蛋白质，它与细胞松弛素B一样，能封闭肌动蛋白丝通常有利于单体添加的末端，并抑制肌动蛋白丝的相互作用。此外，这种“封端”蛋白能使肌动蛋白单体发生成核反应，并阻止肌动蛋白丝片段的退火。
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