Hellström B, Barlach-Christoffersen M
Neuropadiatrie. 1980 May;11(2):151-60. doi: 10.1055/s-2008-1071385.
Eleven preschool children with febrile convulsions or epilepsy were started on phenobarbital. Before treatment was started and at regular intervals after the onset of medication up to one year psychological tests were applied and the behaviour of the children analyzed. The plasma levels of phenobarbital were recorded. A transient deterioration of fine motor functions and behavioural disturbances were found in most children during the first weeks and months. The problems subsided thereafter and at one year follow up the drug-induced changes had disappeared. The need for extended studies is underlined.
11名患有高热惊厥或癫痫的学龄前儿童开始服用苯巴比妥。在开始治疗前以及用药后长达一年的定期时间里，进行了心理测试并分析了儿童的行为。记录了苯巴比妥的血浆水平。在最初的几周和几个月里，大多数儿童出现了精细运动功能的短暂恶化和行为障碍。此后这些问题得到缓解，在一年的随访中，药物引起的变化已经消失。强调了进行进一步研究的必要性。
