红细胞中亚硝基苯的生物转化及谷胱甘肽的作用。

Biotransformation of nitrosobenzene in the red cell and the role of glutathione.

Eyer P, Lierheimer E

Xenobiotica. 1980 Jul-Aug;10(7-8):517-26. doi: 10.3109/00498258009033786.

Abstract

In the red cell nitrosobenzene formed glutathione-sulphinanilide from reduced glutathione, and the corresponding sulphinanilide with the reactive cysteine residues of haemoglobin. 2. Glutathionesulphinanilide was reductively cleaved by an NADPH-linked reductase with formation of free analine half an equivalent of reduced glutathione and half of glutathione sulphinic acid. 3. About three quarters of the aniline produced from nitrosobenzene or phenylhydroxylamine was formed via this pathway within the red cell.

摘要

在红细胞中，亚硝基苯由还原型谷胱甘肽形成谷胱甘肽 - 亚磺酰苯胺，并与血红蛋白的活性半胱氨酸残基形成相应的亚磺酰苯胺。2. 谷胱甘肽 - 亚磺酰苯胺被一种与NADPH相关的还原酶还原裂解，生成游离苯胺、半当量的还原型谷胱甘肽和一半的谷胱甘肽亚磺酸。3. 由亚硝基苯或苯羟胺产生的约四分之三的苯胺是通过红细胞内的这条途径形成的。