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[蛋白质使红细胞致敏的机制与免疫球蛋白及其片段和经福尔马林处理的红细胞表面之间的空间相互关系]

[Relationship between the mechanism of erythrocyte sensitization by proteins and the spatial interrelationship between immunoglobulins and their fragments and the surface of formalin treated erythrocytes].

作者信息

Barban P S

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1980 Jun(6):103-7.

PMID:6893783
Abstract

The methods of serological analysis have been used to study the immunochemical (antibody and antigenic) properties and hemosensitizing activity of a number of immunoglobulin sensitins: immune serum, its fractions (globulin, 7S, 19s, gamma-globulin), as well as pure antibodies and their F(ab)2-and Fab-fragments. According to the findings obtained in this study, the hemosensitizing activity of sensitins may be classified as immunoglobulin activity and antigenic activity. All sensitins have been found to have both immunoglobulin and antigenic activity, with the exception of Fab-fragments having only antigenic activity. The results of this study and their comparison with the known data on the fine structure and properties of IgG form the basis for drawing up the picture of the possible location of IgG and their fragments on the surface of a tanned erythrocyte.

摘要

血清学分析方法已被用于研究多种免疫球蛋白致敏素的免疫化学(抗体和抗原)特性及血敏活性:免疫血清、其组分(球蛋白、7S、19S、γ-球蛋白),以及纯抗体及其F(ab)2和Fab片段。根据本研究获得的结果,致敏素的血敏活性可分为免疫球蛋白活性和抗原活性。已发现所有致敏素均具有免疫球蛋白和抗原活性,但Fab片段仅具有抗原活性。本研究结果及其与关于IgG精细结构和特性的已知数据的比较,为描绘IgG及其片段在鞣酸处理红细胞表面可能的定位情况奠定了基础。

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1
[Relationship between the mechanism of erythrocyte sensitization by proteins and the spatial interrelationship between immunoglobulins and their fragments and the surface of formalin treated erythrocytes].[蛋白质使红细胞致敏的机制与免疫球蛋白及其片段和经福尔马林处理的红细胞表面之间的空间相互关系]
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