华氏巨球蛋白血症和多发性神经病患者单克隆免疫球蛋白M中的交叉独特型抗原。
Cross-idiotypic antigens among monoclonal immunoglobulin M from patients with Waldenström's macroglobulinemia and polyneuropathy.
作者信息
Dellagi K, Brouet J C, Danon F
出版信息
J Clin Invest. 1979 Nov;64(5):1530-4. doi: 10.1172/JCI109612.
Abstract
The monoclonal immunoglobulin (Ig)M from 5 to 16 patients with Waldenström's macroglobulinemia and a polyneuropathy shared cross-idiotypic antigenic determinants as demonstrated by hemagglutination and hemagglutination inhibition experiments as well as by precipitin reactions. This reactivity was located to the Fab (and not Fc) fragment of the protein. The IgM from 73 patients with macroglobulinemia but without neuropathy all gave negative reactions. In contrast, the monoclonal IgG from a patient with polyneuropathy also possessed similar idiotypic determinants. Since cross-idiotypic determinants are usually related to the combining site of a monoclonal Ig, this finding suggests that the monoclonal Ig of these patients may mediate the nerve injury via their antibody activity, which could be directed either to a nerve antigen or to some component involved in the pathogenesis of the neuropathy.
摘要
通过血凝、血凝抑制实验以及沉淀反应证明，5至16例华氏巨球蛋白血症伴多发性神经病患者的单克隆免疫球蛋白（Ig）M具有共同的交叉独特型抗原决定簇。这种反应性定位于该蛋白的Fab（而非Fc）片段。73例无神经病的巨球蛋白血症患者的IgM均呈阴性反应。相比之下，1例多发性神经病患者的单克隆IgG也具有相似的独特型决定簇。由于交叉独特型决定簇通常与单克隆Ig的结合位点相关，这一发现表明这些患者的单克隆Ig可能通过其抗体活性介导神经损伤，该抗体活性可能针对神经抗原或参与神经病发病机制的某些成分。
相似文献
1
Cross-idiotypic antigens among monoclonal immunoglobulin M from patients with Waldenström's macroglobulinemia and polyneuropathy.华氏巨球蛋白血症和多发性神经病患者单克隆免疫球蛋白M中的交叉独特型抗原。
J Clin Invest. 1979 Nov;64(5):1530-4. doi: 10.1172/JCI109612.
2
Crossreacting idiotypes of kappa-monoclonal immunoglobulins M in sera of patients with Waldenström's macroglobulinemia.华氏巨球蛋白血症患者血清中κ链单克隆免疫球蛋白M的交叉反应独特型
Immunobiology. 1987 Dec;176(1-2):144-53. doi: 10.1016/s0171-2985(87)80106-7.
3
Recombination of the polypeptide chains of a Waldenström's IgM that binds IgG.与IgG结合的瓦尔登斯特伦巨球蛋白的多肽链重组。
J Immunol. 1973 Dec;111(6):1699-711.
4
[Waldenström's macroglobulinemia with preserved antierythrocyte and antilipoprotein antibody activity].[伴有保留抗红细胞和抗脂蛋白抗体活性的华氏巨球蛋白血症]
Sem Hop. 1975 Dec 9;51(48):2943-8.
5
Detection of a monoclonal human myeloma protein of IgM and IgG class by carp anti-idiotypic sera.用鲤鱼抗独特型血清检测IgM和IgG类单克隆人骨髓瘤蛋白
Acta Biol Med Ger. 1981;40(6):861-5.
6
Antiidiotypic activity in the IgM fractions of mixed cryoglobulins.混合冷球蛋白IgM组分中的抗独特型活性。
J Immunol. 1980 Oct;125(4):1530-5.
7
A Waldenström's macroglobulin with anti-G3m(b1) antibody activity.一种具有抗G3m(b1)抗体活性的瓦尔登斯特伦巨球蛋白。
J Immunol. 1991 Mar 15;146(6):1880-4.
8
Investigation of the idiotypic determinants of IgM monoclonal proteins associated with neuropathy.与神经病变相关的IgM单克隆蛋白独特型决定簇的研究。
Clin Exp Immunol. 1984 Sep;57(3):621-5.
9
10
B-cell malignancy and monoclonal gammopathy, and idiotype of cell surface and serum immunoglobulin.B细胞恶性肿瘤和单克隆丙种球蛋白病，以及细胞表面和血清免疫球蛋白的独特型。
Jpn J Clin Oncol. 1983 Sep;13(3):533-42.
引用本文的文献
1
Plasma exchange treatment of peripheral neuropathy associated with plasma cell dyscrasia.血浆置换治疗与浆细胞异常增殖相关的周围神经病
J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):813-9. doi: 10.1136/jnnp.47.8.813.
2
Plasma cell dyscrasia and peripheral neuropathy: identification of the myelin antigens that react with human paraproteins.浆细胞异常增生症与周围神经病变：与人类副蛋白发生反应的髓磷脂抗原的鉴定
Proc Natl Acad Sci U S A. 1981 Nov;78(11):7139-42. doi: 10.1073/pnas.78.11.7139.
3
Investigation of the idiotypic determinants of IgM monoclonal proteins associated with neuropathy.与神经病变相关的IgM单克隆蛋白独特型决定簇的研究。
Clin Exp Immunol. 1984 Sep;57(3):621-5.
4
IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside.与副蛋白血症相关的人类神经病变中的IgM与髓鞘相关糖蛋白中的碳水化合物决定簇以及一种神经节苷脂结合。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1225-9. doi: 10.1073/pnas.81.4.1225.
5
Human monoclonal IgM with autoantibody activity against intermediate filaments.具有抗中间丝自身抗体活性的人单克隆IgM
Proc Natl Acad Sci U S A. 1982 Jan;79(2):446-50. doi: 10.1073/pnas.79.2.446.
6
Anti-peripheral nerve myelin antibodies in Guillain-Barre syndrome bind a neutral glycolipid of peripheral myelin and cross-react with Forssman antigen.吉兰-巴雷综合征中的抗周围神经髓鞘抗体与周围髓鞘的一种中性糖脂结合，并与福斯曼抗原发生交叉反应。
J Clin Invest. 1989 Jul;84(1):280-7. doi: 10.1172/JCI114152.
7
Reactivity of sera and isolated monoclonal IgM from patients with Waldenström's macroglobulinaemia with peripheral nerve myelin.华氏巨球蛋白血症患者血清及分离出的单克隆IgM与周围神经髓鞘的反应性
J Neurol. 1985;232(1):43-8. doi: 10.1007/BF00314040.
本文引用的文献
1
Immunoglobulin M: pentameric Fcmu fragments released by trypsin at higher temperatures.免疫球蛋白M：在较高温度下由胰蛋白酶释放的五聚体Fcmu片段。
Proc Natl Acad Sci U S A. 1970 Feb;65(2):318-22. doi: 10.1073/pnas.65.2.318.
2
IgM-producing lymphocytes in peripheral nerve in a patient with benign monoclonal gammopathy.患有良性单克隆丙种球蛋白病患者外周神经中产生IgM的淋巴细胞。
Scand J Haematol. 1973;11(4):332-5. doi: 10.1111/j.1600-0609.1973.tb00137.x.
3
Cross idiotypic specificity among cold agglutinins in relation to combining activity for blood group-related antigens.冷凝集素之间的交叉独特型特异性与血型相关抗原的结合活性的关系。
Clin Exp Immunol. 1974 Oct;18(2):283-93.
4
[Peripheral neuropathy in malignant dysglobulinemias. Immunopathological aspects].[恶性球蛋白血症中的周围神经病变。免疫病理学方面]
Nouv Presse Med. 1974 May 25;3(21):1355-8.
5
Polyneuropathy in Waldenström's macroglobulinaemia.华氏巨球蛋白血症中的多发性神经病
J Neurol Sci. 1974 Mar;21(3):341-54. doi: 10.1016/0022-510x(74)90178-6.
6
Antigenic specificities related to the cold agglutinin activity of gamma M globulins.与γM球蛋白冷凝集素活性相关的抗原特异性。
Science. 1968 Jul 26;161(3839):379-81. doi: 10.1126/science.161.3839.379.
7
Chromic chloride: a coupling reagent for passive hemagglutination reactions.氯化铬：一种用于被动血凝反应的偶联试剂。
J Immunol. 1967 Nov;99(5):859-66.
8
Immunoglobulin abnormalities in families of patients with Waldenström's macroglobulinemia.华氏巨球蛋白血症患者家族中的免疫球蛋白异常
Am J Med. 1967 Jul;43(1):66-83. doi: 10.1016/0002-9343(67)90149-0.
9
Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity.具有抗球蛋白活性的单克隆IgM蛋白之间的交叉独特型特异性。
J Exp Med. 1973 Feb 1;137(2):331-42. doi: 10.1084/jem.137.2.331.
10
Complete amino acid sequence of the variable domains of two human IgM anti-gamma globulins (Lay/Pom) with shared idiotypic specificities.两种具有共同独特型特异性的人IgM抗γ球蛋白（Lay/Pom）可变区的完整氨基酸序列。
Scand J Immunol. 1976;5(6-7):677-84. doi: 10.1111/j.1365-3083.1976.tb03017.x.
Zotero 插件