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低乳糖牛奶的临床研究。

Clinical studies with low-lactose milk.

作者信息

Reasoner J, Maculan T P, Rand A G, Thayer W R

出版信息

Am J Clin Nutr. 1981 Jan;34(1):54-60. doi: 10.1093/ajcn/34.1.54.

Abstract

A low-lactose milk was evaluated for taste acceptance and clinical symptomatology by means of a double-blind control study in two groups of individuals. One group consisted of nine milk intolerant individuals, while the other consisted of five milk tolerant individuals. Each week for 9 wk the participants were given a coded sample of skim milk, lactose hydrolyzed milk, skim milk plus glucose, or sweet acidophilus milk. Each participant was asked to consume four liters of milk during a week and keep a daily log of symptoms (pain, bloating, nausea, flatus, emesis, bowel frequency) along with taste acceptability. After assigning a numerical value to the intensity of symptomatology a X2 analysis was performed on the data. In the milk intolerant population lactose hydrolyzed milk produced significantly milder (p < 0.05) pain and gas symptoms than the nonhydrolyzed milks. Bowel frequency was not altered between the types of milk in both groups. The lactose hydrolyzed milk did not reduce the symptoms of lactose intolerance in the milk intolerance population to the response of the control group. Although both study populations found decreased taste acceptability to the lactose hydrolyzed milk, a taste panel assessment did not show any significant differences in the milks.

摘要

通过一项双盲对照研究,在两组个体中对一种低乳糖牛奶进行了口味接受度和临床症状评估。一组由9名不耐受牛奶的个体组成,另一组由5名耐受牛奶的个体组成。在9周的时间里,每周给参与者提供一份编码的脱脂牛奶、乳糖水解牛奶、脱脂牛奶加葡萄糖或嗜酸乳杆菌牛奶样本。要求每位参与者在一周内饮用4升牛奶,并记录每日症状(疼痛、腹胀、恶心、肠胃胀气、呕吐、排便频率)以及口味接受度。在为症状强度赋予数值后,对数据进行了X2分析。在不耐受牛奶的人群中,乳糖水解牛奶产生的疼痛和气体症状明显比未水解的牛奶轻(p < 0.05)。两组中不同类型牛奶之间的排便频率没有改变。乳糖水解牛奶并没有将不耐受牛奶人群中乳糖不耐受的症状减轻到对照组的反应程度。尽管两个研究人群都发现乳糖水解牛奶的口味接受度有所下降,但口味小组评估并未显示出这些牛奶之间有任何显著差异。

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