哌仑西平和阿托品对胃壁跨膜黏膜电位差的影响（作者译）
[Effect of pirenzepine and atropine on the transmural gastric mucosal potential difference (author's transl)].
作者信息
von Kleist D, Staud R, Stopik D, Hampel H E
出版信息
Dtsch Z Verdau Stoffwechselkr. 1980;40(3-4):110-4.
PMID:6893819
Abstract
The transmural gastric mucosal potential difference (PD) measured by endoscopy has proved to be a good parameter in evaluating dose dependent effects of drugs. In 43 volunteers the maximum increases of the PD taken from the gastric juice were found after 30 mg pirenzepine and 0,5 and I mg atropin within 16 minutes. There was a significant difference between 20 and 30 mg pirenzepin. The dose of 20 mg pirenzepin seems to be insufficient to induce a maximum increase of PD in each individual.
摘要
经内镜测量的跨壁胃黏膜电位差（PD）已被证明是评估药物剂量依赖性效应的良好参数。在43名志愿者中，发现服用30毫克哌仑西平和0.5毫克及1毫克阿托品后16分钟内，胃液中PD的最大增加值出现。20毫克和30毫克哌仑西平之间存在显著差异。20毫克哌仑西平的剂量似乎不足以使每个个体的PD达到最大增加值。
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