[Effect of cimetidine on the transmural gastric mucosal potential difference including the histological pattern of the gastric mucosa (author's transl)].

The measurement of gastric mucosal potential difference (PD) has proved to be a good parameter in the observation of changes in the permeability and the ionic transport of the gastric mucosa. 48 volunteers were examined. The aim of the study was to show if cimetidine induced a dose-dependent increase in the potential difference and if this was infuenced by the different regions of the stomach and morphologic pattern of the gastric mucosa. After 100, 200 and 400 mg cimetidine intravenously there was a maximum increase of the potential difference in the different regions of the stomach and in the gastric juice independent from the dose schedule. No changes were seen in the duodenum. The extent of the increase in PD was dependent on the lesions of the gastric mucosa and the different regions of the stomach.