Fresko D, Lazarus S S
Arch Pathol Lab Med. 1981 Jan;105(1):15-9.
We studied a tumor of the oral mucosa that initially appeared as an intraepithelial carcinoma, and then progressed after one year to invasive squamous carcinoma and after eight years to basal-cell carcinoma (BCC) with admixture of basosquamous and squamous carcinomas. This tumor, which originated from basal cells, reflects the ability of these cells to produce neoplasms that range from those consisting of least-mature elements (basal cells) to mature ones (squamous cells), with intermediary types that contain both elements (basosquamous carcinoma). These transformations imply that BCCs can arise from the basal layer of skin and oral mucosa and that the terms BCC, basosquamous carcinoma, and squamous carcinoma are descriptive rather than of histogenetic significance.
我们研究了一例口腔黏膜肿瘤，该肿瘤最初表现为上皮内癌，一年后进展为浸润性鳞状癌，八年后进展为基底细胞癌（BCC），伴有基底鳞状癌和鳞状癌混合成分。这种起源于基底细胞的肿瘤反映了这些细胞产生肿瘤的能力，这些肿瘤范围从由最不成熟成分（基底细胞）组成的肿瘤到成熟成分（鳞状细胞）组成的肿瘤，还有包含两种成分的中间类型（基底鳞状癌）。这些转变意味着BCC可起源于皮肤和口腔黏膜的基底层，并且BCC、基底鳞状癌和鳞状癌这些术语是描述性的，而非具有组织发生学意义。
