McDowell E M, Wilson T S, Trump B F
Arch Pathol Lab Med. 1981 Jan;105(1):20-8.
Seven malignant peripheral lung tumors that were diagnosed using light microscopy as large-cell carcinomas or as epidermoid or adenocarcinomas were studied by light and electron microscopic histochemistry. All tumors contained numerous dense-core granules. The cells were joined by desmosomes and contained well-developed tonofilament bundles. Serotonin was demonstrated in six of seven tumors and argyrophilic granules were demonstrated in five of six tumors tested. Four tumors produced mucus. All tumors extended to the visceral pleura and two invaded the chest wall. The existence of lung tumors that contain serotonin and bear argyrophilic putative endocrine granules, but that do not have a light-microscopic histology characteristic of either carcinoid or oat-cell carcinomas, is confirmed. The presumptive endocrine nature of such tumors usually passes unrecognized because they lack criteria to allow diagnosis by routine methods.
对七例经光学显微镜诊断为大细胞癌、表皮样癌或腺癌的恶性周围型肺肿瘤进行了光镜和电镜组织化学研究。所有肿瘤均含有大量致密核心颗粒。细胞通过桥粒连接，含有发育良好的张力丝束。七例肿瘤中有六例检测到5-羟色胺，六例检测的肿瘤中有五例检测到嗜银颗粒。四例肿瘤产生黏液。所有肿瘤均累及脏层胸膜，两例侵犯胸壁。证实存在含有5-羟色胺并带有嗜银性假定内分泌颗粒，但在光学显微镜下没有类癌或燕麦细胞癌组织学特征的肺肿瘤。此类肿瘤的假定内分泌性质通常未被认识到，因为它们缺乏通过常规方法进行诊断的标准。
