Harach H R, Skinner M, Gibbs A R
Thorax. 1983 Dec;38(12):937-41. doi: 10.1136/thx.38.12.937.
Immunohistological methods were used to investigate the presence of calcitonin, thyrotrophin, carcinoembryonic antigen, beta pregnancy specific glycoprotein, human placental lactogen, and the beta subunit of human chorionic gonadotrophin in formalin fixed lung tumour tissue sections. Carcinoembryonic antigen was observed in 71% of 101 tumours studied (70%), beta 1 pregnancy specific glycoprotein in 66 of 97 tumours (68%), beta subunit of human chorionic gonadotrophin in 35 of 97 (36%), human placental lactogen in 19 of 97 (20%), calcitonin in 10 of 71 (14%), and thyrotrophin in one of 27 lung tumours studied. There appeared to be no direct association between the presence of any given marker and the presence of any other. Similarly, the association between the presence of a tumour marker and histological type was poor. This study shows that the presence of tumour markers is relatively common in human lung tumours.
采用免疫组织学方法研究福尔马林固定的肺肿瘤组织切片中降钙素、促甲状腺激素、癌胚抗原、β妊娠特异性糖蛋白、人胎盘催乳素及人绒毛膜促性腺激素β亚基的存在情况。在所研究的101个肿瘤中，71%（70个）观察到癌胚抗原，97个肿瘤中有66个（68%）观察到β1妊娠特异性糖蛋白，97个中有35个（36%）观察到人绒毛膜促性腺激素β亚基，97个中有19个（20%）观察到人胎盘催乳素，71个中有10个（14%）观察到降钙素，在所研究的27个肺肿瘤中有1个观察到促甲状腺激素。任何一种特定标志物的存在与其他标志物的存在之间似乎没有直接关联。同样，肿瘤标志物的存在与组织学类型之间的关联也较弱。本研究表明，肿瘤标志物在人类肺肿瘤中相对常见。
