Tanaka T, Yamaguchi T, Kuma K, Hidaka H
Endocrinol Jpn. 1980 Aug;27(4):447-50. doi: 10.1507/endocrj1954.27.447.
The effect of propranolol on plasma dopamine-beta-hydroxylase activity and triiodothyronine was investigated in twelve subjects with Graves' disease. Plasma DBH activity, serum triiodothyronine and thyroxine were determined beforehand and electrocardiograms were recorded on the same days as the blood samples were taken. Propranolol administration was associated with clinical amelioration in blood pressure and ECG. There was a positive and significant correlation between changes in DBH activity and triiodothyronine caused by propranolol. These data offer evidence that there may be an interaction between plasma DBH activity and triiodothyronine during propranolol administration in hyperthyroidism.
在12例格雷夫斯病患者中研究了普萘洛尔对血浆多巴胺-β-羟化酶活性和三碘甲状腺原氨酸的影响。预先测定血浆DBH活性、血清三碘甲状腺原氨酸和甲状腺素，并在采集血样的同一天记录心电图。给予普萘洛尔与血压和心电图的临床改善相关。普萘洛尔引起的DBH活性变化与三碘甲状腺原氨酸变化之间存在正相关且具有显著性。这些数据提供了证据，表明在甲状腺功能亢进症患者服用普萘洛尔期间，血浆DBH活性与三碘甲状腺原氨酸之间可能存在相互作用。
