Wiersinga W M, Touber J L
J Clin Endocrinol Metab. 1977 Aug;45(2):293-8. doi: 10.1210/jcem-45-2-293.
The effect of the beta-adrenoceptor blocking agent propranolol on plasma levels of thyroxine and triiodothyronine was studied in eleven hyperthyroid patients and in six hypothyroid patients on L-thyroxine substitution therapy. In all patients a decrease in plasma-triiodothyronine was found. The per cent decrease of plasma-triiodothyronine was the same in both groups. Plasma levels of thyroxine and thyrotropin increased in the hypothyroid patients, but remained constant in the hyperthyroid subjects. The decrease in plasma-triiodothyronine during propranolol medication is most likely caused by an inhibition of the peripheral conversion of thyroxine into triiodothyronine.
在11例甲状腺功能亢进患者和6例接受左旋甲状腺素替代治疗的甲状腺功能减退患者中，研究了β-肾上腺素受体阻滞剂普萘洛尔对血浆甲状腺素和三碘甲状腺原氨酸水平的影响。在所有患者中均发现血浆三碘甲状腺原氨酸水平降低。两组血浆三碘甲状腺原氨酸的降低百分比相同。甲状腺功能减退患者的血浆甲状腺素和促甲状腺激素水平升高，但甲状腺功能亢进患者的这些水平保持不变。普萘洛尔用药期间血浆三碘甲状腺原氨酸的降低很可能是由于甲状腺素向三碘甲状腺原氨酸的外周转化受到抑制所致。
