Amino N, Kuro R, Yabu Y, Takai S I, Kawashima M, Morimoto S, Ichihara K, Miyai K, Kumahara Y
J Clin Endocrinol Metab. 1981 Mar;52(3):457-62. doi: 10.1210/jcem-52-3-457.
The level of circulating carcinoembryonic antigen (CEA) was measured in 148 patients with various thyroid diseases. A significantly high frequency of positive CEA was observed in hypothyroid patients with Hashimoto's disease, but the serum CEA levels were not correlated with the serum calcitonin concentrations in Hashimoto's disease. The CEA levels were inversely correlated with the serum T4 concentrations (P less than 0.001) and were positively correlated with the serum TSH concentrations (P less than 0.001), but not with the titers of serum antithyroid antibodies or the size of goiter in autoimmune thyroid disease. Moreover, the increase in CEA was significantly related to the duration of hypothyroidism (P less than 0.001). The high CEA levels in all hypothyroid patients decreased when the patients attained a euthyroid state after thyroid hormone therapy for 4-9 months. The gradual decrease in the serum CEA levels during treatment was roughly correlated with the decreases in serum cholesterol concentration and serum lactic dehydrogenase and glutamic oxalacetic transaminase activities. On Sephadex G-200 column chromatography of serum from hypothyroid patients, the CEA immunoreactivity, like purified standard CEA, was recovered in the large molecular weight fraction. These findings indicate that elevated CEA levels in hypothyroid patients do not necessarily indicate malignancy. CEA elevation in hypothyroidism may be caused by decreased degradation of CEA.
对148例患有各种甲状腺疾病的患者测定了循环癌胚抗原（CEA）水平。在患有桥本氏病的甲状腺功能减退患者中观察到CEA阳性的频率显著较高，但在桥本氏病中血清CEA水平与血清降钙素浓度无关。CEA水平与血清T4浓度呈负相关（P<0.001），与血清促甲状腺激素（TSH）浓度呈正相关（P<0.001），但与自身免疫性甲状腺疾病中的血清抗甲状腺抗体滴度或甲状腺肿大小无关。此外，CEA升高与甲状腺功能减退的持续时间显著相关（P<0.001）。所有甲状腺功能减退患者在接受4至9个月的甲状腺激素治疗达到甲状腺功能正常状态后，其高CEA水平均下降。治疗期间血清CEA水平的逐渐下降大致与血清胆固醇浓度、血清乳酸脱氢酶和谷草转氨酶活性的下降相关。对甲状腺功能减退患者的血清进行Sephadex G - 200柱层析时，CEA免疫反应性与纯化的标准CEA一样，在大分子部分被回收。这些发现表明，甲状腺功能减退患者中CEA水平升高不一定表明存在恶性肿瘤。甲状腺功能减退时CEA升高可能是由于CEA降解减少所致。
