Cheng Yu-Cheng, Li Yu-Hsuan, Hsu Chiann-Yi, Lee I-Te
Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Graduate Institute of Data Science, Taipei Medical University, Taipei, Taiwan.
Diabetes Metab Syndr Obes. 2020 Jun 10;13:1933-1942. doi: 10.2147/DMSO.S256223. eCollection 2020.
Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are tumor-associated antigens. An increased serum level of CEA and CA19-9 separately has been reported in diabetes. In this study, we examined the composite effect of elevated serum levels of both CEA and CA19-9 on subjects with type 2 diabetes and prediabetes.
A total of 3568 adults who attended a health examination were enrolled into this cross-sectional study. Subjects were grouped into four groups according to the median serum CEA and CA19-9 levels.
Subjects with high CEA and high CA19-9 levels had the highest proportions of diabetes (43.9%) and prediabetes (33.04%). There was a statistically significant trend in the proportion of diabetes across the four groups (P < 0.001). Multivariable logistic regression analysis revealed higher risks of type 2 diabetes in subjects with high CEA and low CA19-9 levels (odds ratio [OR] = 2.10, 95% confidence interval [CI]: 1.39-3.18, P < 0.001) and in those with high CA19-9 and low CEA levels (OR = 2.18, 95% CI: 1.42-3.34, P < 0.001) than in those with low CEA and low CA19-9 levels; among these four groups, the highest risk of type 2 diabetes was observed in subjects with high CEA and high CA19-9 levels (OR = 2.65, 95% CI: 1.81-3.88, P < 0.001). The risk of prediabetes was significantly higher only in subjects with high CEA and high CA19-9 levels compared to those with low CEA and low CA19-9 levels (OR = 1.32, 95% CI: 1.08-1.61, P = 0.006).
CEA and CA19-9 had a synergistic ability to increase the risk of type 2 diabetes and prediabetes.
癌胚抗原（CEA）和糖类抗原19-9（CA19-9）是肿瘤相关抗原。据报道，糖尿病患者中血清CEA和CA19-9水平分别升高。在本研究中，我们检测了血清CEA和CA19-9水平均升高对2型糖尿病和糖尿病前期患者的综合影响。
共有3568名参加健康体检的成年人纳入本横断面研究。根据血清CEA和CA19-9水平中位数将受试者分为四组。
CEA和CA19-9水平均高的受试者中糖尿病（43.9%）和糖尿病前期（33.04%）的比例最高。四组中糖尿病比例存在统计学显著趋势（P<0.001）。多变量逻辑回归分析显示，CEA水平高而CA19-9水平低的受试者（比值比[OR]=2.10，95%置信区间[CI]：1.39-3.18，P<0.001）以及CA19-9水平高而CEA水平低的受试者（OR=2.18，95%CI：1.42-3.34，P<0.001）患2型糖尿病的风险高于CEA和CA19-9水平均低的受试者；在这四组中，CEA和CA19-9水平均高的受试者患2型糖尿病的风险最高（OR=2.65，95%CI：1.81-3.88，P<0.001）。与CEA和CA19-9水平均低的受试者相比，仅CEA和CA19-9水平均高的受试者患糖尿病前期的风险显著更高（OR=1.32，95%CI：1.08-1.61，P=0.006）。
CEA和CA19-9具有协同增加2型糖尿病和糖尿病前期风险的能力。
