肥大诱导的血管平滑肌中间丝增加。
Hypertrophy-induced increase of intermediate filaments in vascular smooth muscle.
作者信息
Berner P F, Somlyo A V, Somlyo A P
出版信息
J Cell Biol. 1981 Jan;88(1):96-100. doi: 10.1083/jcb.88.1.96.
Abstract
The distribution of filaments was studied in hypertrophied rabbit vascular smooth muscle. Hypertrophy was induced by partial ligation of the portal-anterior mesenteric vein. 14 d after ligation, there was an approximately threefold increase in the number of intermediate filaments per cross-sectional area, as compared to control values. The actin:intermediate:myosin filament ratio was 15:1.1:1 in control and 15:3.5:0.5 in hypertrophied portal-anterior mesentric vein vascular smooth muscle. Comparison of the filament ratios with the increase in volume density of the hypertrophied cells suggests that the number of myosin filaments per cell profile remained approximately the same as in controls, whereas the number of actin filaments increased in proportion to the increase in cell volume.
摘要
研究了肥厚兔血管平滑肌中细丝的分布情况。通过门静脉-肠系膜前静脉部分结扎诱导肥厚。结扎后14天，与对照值相比，每横截面积中间丝的数量增加了约三倍。在对照中，肌动蛋白：中间丝：肌球蛋白丝的比例为15:1.1:1，在肥厚的门静脉-肠系膜前静脉血管平滑肌中为15:3.5:0.5。将细丝比例与肥厚细胞的体积密度增加进行比较表明，每个细胞轮廓中肌球蛋白丝的数量与对照中大致相同，而肌动蛋白丝的数量与细胞体积的增加成比例增加。
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