Jackson B A
J Am Vet Med Assoc. 1980 May 15;176(10 Spec No):1141-4.
The safety assessment of drug residues is part of the process for defining the conditions for the safe use of drugs in food-producing animals. The information needed to assess the safety of drug residues is provided by chemical and toxicity tests. Toxicity tests are conducted to identify the type of effect produced and to determine the exposure concentrations that would be expected not to produce the effect. These tests include acute, subacute, and chronic toxicity tests, as well as reproduction studies and other special tests. The results are used to find an acceptable daily intake for drug residues that can be used to set a tolerance.
药物残留的安全性评估是确定食用动物安全用药条件过程的一部分。评估药物残留安全性所需的信息由化学和毒性测试提供。进行毒性测试以确定所产生的效应类型，并确定预期不会产生该效应的暴露浓度。这些测试包括急性、亚急性和慢性毒性测试，以及生殖研究和其他特殊测试。结果用于确定药物残留的每日可接受摄入量，该摄入量可用于设定耐受量。
