Nilsson R, Grossmann G, Robertson B
Respiration. 1980;40(4):218-25. doi: 10.1159/000194280.
Premature newborn rabbits, delivered on day 27 of gestation, were ventilated for 10 min with a standardized peak pressure of 35 cm H2O, with or without previous instillation of natural surfactant into the airways. Lung-thorax compliance and stability were significantly enhanced in surfactant-treated fetuses. Although these fetuses were greatly overventilated, their tendency to develop bronchiolar epithelial lesions was significantly reduced in comparison with controls; this was verified by light as well as electron microscopy. Our findings argue against barotrauma as the cause of bronchiolar epithelial lesions during artificial ventilation, and favor the concept that these lesions reflect an abnormal expansion pattern due to surfactant deficiency.
妊娠27天出生的早产新生兔，用35厘米水柱的标准峰值压力通气10分钟，气道内预先滴注或未滴注天然表面活性剂。表面活性剂治疗的胎儿肺胸顺应性和稳定性显著增强。尽管这些胎儿通气过度，但与对照组相比，其发生细支气管上皮病变的倾向显著降低；这通过光学显微镜和电子显微镜得到了证实。我们的研究结果反对气压伤是人工通气期间细支气管上皮病变的原因，支持这些病变反映由于表面活性剂缺乏导致的异常扩张模式这一观点。
