Florentin I, Schulz J, Bruley-Rosset M, Kiger N, Martinez J, Mathé G
Recent Results Cancer Res. 1980;75:153-61. doi: 10.1007/978-3-642-81491-4_24.
Mice were submitted to various immunologic tests at different times after a single intravenous (IV) injection of azimexon or tuftsin in order to determine the mode of action of these chemically defined immunomodulators. Azimexon, (BM 12,531) an aziridine derivative, potentiated antibody responses to both thymus-dependent (TNP-KLH) and thymus-independent (TNP-LPS) antigens and DTH reaction to oxazolone when injected at least 1 day before the antigen. It activated macrophages, rendering them cytostatic for tumor cells, but depressed ADCC activity of spleen cells directed against antibody-coated CRBC. Tuftsin, a basic tetrapeptide, potentiated antibody response to TNP-KLH when injected at least 3 days before the antigen. The response to TNP-LPS was stimulated on days 1 and 3, but was slightly depressed on day 7. It rendered macrophages highly cytostatic for tumor cells but, as observed with azimexon, the activation process required 7 days to develop. ADCC was enhanced throughout the period of observation.
在单次静脉注射氮咪腙或促吞噬肽后的不同时间，对小鼠进行各种免疫学测试，以确定这些化学结构明确的免疫调节剂的作用方式。氮咪腙（BM 12,531），一种氮丙啶衍生物，在抗原注射前至少1天注射时，可增强对胸腺依赖性（TNP-KLH）和胸腺非依赖性（TNP-LPS）抗原的抗体反应以及对恶唑酮的迟发型超敏反应。它激活巨噬细胞，使其对肿瘤细胞具有细胞毒性，但会降低脾细胞针对抗体包被的CRBC的ADCC活性。促吞噬肽，一种碱性四肽，在抗原注射前至少3天注射时，可增强对TNP-KLH的抗体反应。对TNP-LPS的反应在第1天和第3天受到刺激，但在第7天略有下降。它使巨噬细胞对肿瘤细胞具有高度细胞毒性，但与氮咪腙一样，激活过程需要7天才能显现。在整个观察期内，ADCC均增强。
