Klioua R, Mornex R, Berthezene F, Fitoussi R
Ann Endocrinol (Paris). 1980 Nov-Dec;41(6):614-7.
135 patients with goiter treated for Graves' disease have been followed during 10 years (12) 5 to 1 years (64) 1 to 5 years (59) after surgical treatment. The incidence of hypothyroidism increases with the delay (23 % after 1 year, 32,6 % after 5 years, 37,8 % after 10 years). The incidence of relapses is similar (7,4 % after 1 year, 15,5 % after 5 years, 22,2 % after 10 years). There is no predictive value of clinical and biological data. Only the limits of thyroidectomy and the pathological findings can inform on the post operative evolution : relapses are more frequent after subtotal bilateral thyroidectomy, hypothyroidism is more frequent after one total lobectomy + subtotal lobectomy on the other side and in the case of large lymphocytic infiltration.
135例因格雷夫斯病接受治疗的甲状腺肿患者在手术治疗后的10年(12例)、5至1年(64例)、1至5年(59例)期间接受了随访。甲状腺功能减退的发生率随时间延迟而增加(1年后为23%,5年后为32.6%,10年后为37.8%)。复发率相似(1年后为7.4%,5年后为15.5%,10年后为22.2%)。临床和生物学数据没有预测价值。只有甲状腺切除术的范围和病理结果能够提示术后的病情演变:双侧次全甲状腺切除术后复发更常见,一侧全叶切除+另一侧次全叶切除术后以及存在大量淋巴细胞浸润时甲状腺功能减退更常见。