γ-氯正缬氨酸，一种来自链霉菌的亮氨酸类似物。

gamma-Chloronorvaline, a leucine analog from Streptomyces.

作者信息

Narayanan S, Iyengar M R, Ganju P L, Rengaraju S, Shomura T, Tsuruoka T, Inouye S, Niida T

出版信息

J Antibiot (Tokyo). 1980 Nov;33(11):1249-55. doi: 10.7164/antibiotics.33.1249.

DOI:10.7164/antibiotics.33.1249

Abstract

gamma-Chloronorvaline (AL-719) and gamma-hydroxynorvalinelactone (AL-719Y) were isolated from the culture broth of Streptomyces griseosporeus AL-719. Physico-chemical studies led to the structure elucidation of AL-719 and 719Y, with there respective configurations of (2S, 4S) and (2S, 4R). AL-719 shows antibacterial activity on a synthetic agar, especially against Pseudomonas aeruginosa, which was reversed by L-leucine. The producing strain AL-719 was characterized.

摘要

γ-氯正缬氨酸（AL-719）和γ-羟基正缬氨酸内酯（AL-719Y）是从灰色链霉菌AL-719的培养液中分离得到的。通过物理化学研究确定了AL-719和719Y的结构，其构型分别为(2S, 4S)和(2S, 4R)。AL-719在合成琼脂上表现出抗菌活性，尤其对铜绿假单胞菌有抗菌作用，L-亮氨酸可逆转这种作用。对产生菌株AL-719进行了特性鉴定。