猪胰高血糖素原（胰高血糖素原）的一级结构。

The primary structure of porcine glicentin (proglucagon).

作者信息

Thim L, Moody A J

出版信息

Regul Pept. 1981 May;2(2):139-50. doi: 10.1016/0167-0115(81)90007-0.

Abstract

The primary structure of porcine glicentin has been established. The molecule consists of 69 amino acid residues and has a molecular weight of 8128. The sequence of glicentin 1-30 represents the glicentin-related pancreatic peptide (GRPP) previously isolated from porcine pancreas. The sequence 33-61 represents the full sequence of glucagon and the sequence 64-69 is a C-terminal hexapeptide. These three sequences, GRPP, glucagon and the hexapeptide are linked by two Lys-Arg pairs which probably represent the sites for post-synthetic enzymatic cleavages. Glicentin thus fulfils the structural requirements for being proglucagon.

摘要

猪胰高血糖素原的一级结构已被确定。该分子由69个氨基酸残基组成，分子量为8128。胰高血糖素原1 - 30的序列代表了先前从猪胰腺中分离出的胰高血糖素相关胰肽（GRPP）。序列33 - 61代表胰高血糖素的完整序列，序列64 - 69是一个C端六肽。这三个序列，即GRPP、胰高血糖素和六肽，由两个Lys-Arg对相连，这两个对可能代表合成后酶切位点。因此，胰高血糖素原满足了作为胰高血糖素原的结构要求。