白三烯C4和D4可诱导大鼠腹腔巨噬细胞释放前列腺素和血栓素。
Leukotrienes C4 and D4 induce prostaglandin and thromboxane release from rat peritoneal macrophages.
作者信息
Feuerstein N, Foegh M, Ramwell P W
出版信息
Br J Pharmacol. 1981 Mar;72(3):389-91. doi: 10.1111/j.1476-5381.1981.tb10988.x.
Abstract
The present study examined the effect of leukotrienes C4 and D4, the products of the 5'lipoxygenase pathway on prostaglandins and thromboxane release from rat peritoneal macrophages. Incubation of rat peritoneal macrophages with leukotrienes C4 and D4 enhanced the release of prostaglandin E2 (PGE2), 6-keto PGF1 alpha and thromboxane B2 (TxB2) in a dose-dependent manner. The increase of PGE2 was more pronounced than that of 6-keto-PGF1 alpha and TxB2. Lipopolysaccharide, a known stimulator of these cells elicited a similar pattern of increase of the arachidonate metabolites assayed. These results suggest that leukotrienes C4 and D4 are potential activators of macrophages. Since leukotrienes C4 and D4 are produced by these cells, it is suggested that endogenous leukotrienes may be involved in activation of macrophages.
摘要
本研究检测了5-脂氧合酶途径产物白三烯C4和D4对大鼠腹腔巨噬细胞前列腺素和血栓烷释放的影响。用白三烯C4和D4孵育大鼠腹腔巨噬细胞，可剂量依赖性地增强前列腺素E2（PGE2）、6-酮-前列腺素F1α和血栓烷B2（TxB2）的释放。PGE2的增加比6-酮-前列腺素F1α和TxB2更明显。脂多糖是这些细胞的已知刺激物，可引发所检测的花生四烯酸代谢产物的类似增加模式。这些结果表明，白三烯C4和D4是巨噬细胞的潜在激活剂。由于这些细胞可产生白三烯C4和D4，提示内源性白三烯可能参与巨噬细胞的激活。
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