Kitterman J A, Liggins G C, Campos G A, Clements J A, Forster C S, Lee C H, Creasy R K
J Appl Physiol Respir Environ Exerc Physiol. 1981 Aug;51(2):384-90. doi: 10.1152/jappl.1981.51.2.384.
We studied the relationship of certain fetal and maternal hormones to indicators of lung maturation in 12 fetal lambs delivered at gestational ages (GA) of 123-149 days. Maternal estrogen, maternal progesterone, and fetal prolactin did not correlate with GA or the indicators of fetal lung maturation. Fetal cortisol (range 4-165 ng X ml-1) increased with advancing GA (r = 0.747, P less than 0.01). All of the following showed a wide range of late gestation and showed a significant positive correlation with fetal cortisol: lung volumes at 40 cmH2O and 10 cmH2O on the deflation during air pressure-volume studies; saturated phosphatidylcholine (SPC) in lung tissue and in lavage fluid expressed both as mg X g-1 of wet lung and as percent of total phospholipids (%PL); total SPC (lung tissue plus lavage fluid): and SPC in lavage fluid as percent of total SPC. Lung DNA correlated inversely with GA and cortisol. All variables (except lavage fluid SPC as %PL) correlated more closely with cortisol than GA. Morphological development of lung was also related more closely to cortisol than GA. These results suggest that functional lung maturity is attained late in gestation and that endogenous cortisol is an important physiological factor in control of fetal lung maturation.
我们研究了12只孕龄（GA）为123 - 149天的胎羊中某些胎儿和母体激素与肺成熟指标之间的关系。母体雌激素、母体孕酮和胎儿催乳素与GA或胎儿肺成熟指标均无相关性。胎儿皮质醇（范围为4 - 165 ng·ml⁻¹）随GA增加而升高（r = 0.747，P < 0.01）。以下各项在妊娠晚期均呈现广泛变化，且与胎儿皮质醇呈显著正相关：气压 - 容量研究中呼气时40 cmH₂O和10 cmH₂O时的肺容量；肺组织和灌洗液中的饱和磷脂酰胆碱（SPC），以每克湿肺毫克数（mg·g⁻¹）和总磷脂百分比（%PL）表示；总SPC（肺组织加灌洗液）；以及灌洗液中SPC占总SPC的百分比。肺DNA与GA和皮质醇呈负相关。所有变量（灌洗液中SPC作为%PL除外）与皮质醇的相关性比与GA的相关性更紧密。肺的形态发育与皮质醇的关系也比与GA的关系更紧密。这些结果表明，功能性肺成熟在妊娠晚期实现，内源性皮质醇是控制胎儿肺成熟的重要生理因素。
