Sharp B, Reed A W, Tamagra E I, Geffner D L, Hershman J M
J Clin Endocrinol Metab. 1981 Sep;53(3):622-5. doi: 10.1210/jcem-53-3-622.
Ten patients with hyperthyroidism due to Graves' disease were treated with sodium ipodate (1 g daily) in addition to propranolol (P) plus propylthiouracil (PTU; 100 mg every 8 h) and were compared with a control group of 8 patients treated with P and PTU. Patients on P and PTU had a mean (+/- SEM) basal free T3 index of 387 +/- 59 (normal, 70--160) compared with that of 409 +/- 47 (P greater than 0.05) in the sodium ipodate group. The respective basal free T4 index values (normal, 4.5-10.9) were 21.3 +/- 2.8 for the controls and 25.9 +/- 2.8 for the ipodate group (P greater than 0.5), and the basal rT3 values were 192 +/- 49 and 210 +/- 41 (normal, 16--50 ng/dl; P greater than 0.05). The average percent changes in each thyroid index and rT3 were calculated. The first 3 days on P and PTU served as the basal period for the control group, and comparisons were made to the following 9 days. The ipodate group received P and PTU for 2.7 +/- 3.0 days, and comparisons were made with the interval on ipodate, P, and PTU (mean, 9.1 +/- 0.9 days). For the free T3 index, the control group showed a mean decrement of 20.5 +/- 4.4% compared with 50.2 +/- 3.1% for the ipodate group (P less than 0.001). The respective free T4 index decrements were 14.5 +/- 4.4% and 18.5 +/- 2.7% (P greater than 0.05). The respective changes in rT3 were -13.4 +/- 7.6% and +140 +/- 26.9% (P less than 0.001). In patients with hyperthyroidism, short term daily therapy with sodium ipodate plus P and PTU produces a greater reduction of free T3 index values than that caused by P and PTU alone.
10例格雷夫斯病所致甲状腺功能亢进患者，除接受普萘洛尔（P）加丙硫氧嘧啶（PTU，每8小时100mg）治疗外，还接受碘泊酸钠（每日1g）治疗，并与8例接受P和PTU治疗的对照组患者进行比较。接受P和PTU治疗的患者基础游离T3指数平均（±标准误）为387±59（正常范围70 - 160），碘泊酸钠组为409±47（P＞0.05）。对照组基础游离T4指数值（正常范围4.5 - 10.9）为21.3±2.8，碘泊酸钠组为25.9±2.8（P＞0.5），基础反三碘甲状腺原氨酸（rT3）值分别为192±49和210±41（正常范围16 - 50ng/dl；P＞0.05）。计算了每个甲状腺指数和rT3的平均变化百分比。对照组以接受P和PTU治疗的前3天作为基础期，并与随后的9天进行比较。碘泊酸钠组接受P和PTU治疗2.7±3.0天，并与接受碘泊酸钠、P和PTU治疗的时间段（平均9.·1±0.9天）进行比较。对于游离T3指数，对照组平均下降20.5±4.4%，而碘泊酸钠组为50.2±3.1%（P＜0.001）。游离T4指数下降幅度分别为14.5±4.4%和18.5±2.7%（P＞0.05）。rT3的变化分别为 - 13.4±7.6%和 + 140±26.9%（P＜0.001）。在甲状腺功能亢进患者中，碘泊酸钠联合P和PTU短期每日治疗比单独使用P和PTU能使游离T3指数值降低得更多。
