Guseĭnov I A
Probl Endokrinol (Mosk). 1981 Sep-Oct;27(5):20-4.
Chemical composition of the thyroid tissue, removed by surgery, was studied in 72 patients with goiter. Thyrotoxicosis of different severity was found out in 42 and euthyrosis in 30 subjects. The water and dry residue contents, the amounts of extracted and insoluble tissue, collagen level in the thyroid normal tissue and that of different goiter forms were detected. The urine hydroxyproline concentration was determined before surgery. The study of the thyroid tissue chemical composition in modular euthyroid and diffuse toxic goiter has shown a fall in the dry residue and collagen contents, a rise in the water and insoluble tissue levels, an enhancement of the soluble to insoluble tissue ration in comparison with the control. Hyperoxyprolinuria, most pronounced in severe thyrotoxicosis, was seen in patients with various goiter forms versus healthy subjects.
对72例甲状腺肿患者手术切除的甲状腺组织的化学成分进行了研究。42例患者存在不同严重程度的甲状腺毒症，30例甲状腺功能正常。检测了甲状腺正常组织以及不同甲状腺肿形态的水和干残渣含量、提取和不溶性组织量、胶原蛋白水平。术前测定尿羟脯氨酸浓度。对结节性甲状腺功能正常和弥漫性毒性甲状腺肿的甲状腺组织化学成分研究表明，与对照组相比，干残渣和胶原蛋白含量下降，水和不溶性组织水平升高，可溶性与不溶性组织比例增加。与健康受试者相比，各种甲状腺肿形态的患者均出现高氧脯氨酸尿症，在严重甲状腺毒症中最为明显。
