Scholten T, Fritsch W P, Müller J E, Hanrath R, Strohmeyer G
Z Gastroenterol. 1981 Jul;19(7):323-8.
In 8 outpatients with duodenal ulcer the effect of a single dose of 50 mg pirenzepine is compared to a 3-7 days treatment with 2x50 mg. Basal and peptone-stimulated acid output is measured. A single dose of 50 mg pirenzepine reduced basal acid output by 39,9% and the stimulated acid secretion by 21,3%. Treatment for 3-7 days with 2x50 mg pirenzepine is significantly more effective. Basal acid output is reduced by 75,1% and stimulated acid output by 54,0%. No acid inhibition can be demonstrated 12 hours after the last drug administration. Basal serum gastrin levels are little but significantly increased after chronic treatment.
在8例十二指肠溃疡门诊患者中，将单次服用50毫克哌仑西平的效果与服用2×50毫克、疗程为3 - 7天的治疗效果进行了比较。测量了基础胃酸分泌量和蛋白胨刺激后的胃酸分泌量。单次服用50毫克哌仑西平可使基础胃酸分泌量降低39.9%，刺激后的胃酸分泌量降低21.3%。服用2×50毫克哌仑西平进行3 - 7天的治疗效果显著更佳。基础胃酸分泌量降低了75.1%，刺激后的胃酸分泌量降低了54.0%。在最后一次给药12小时后未显示出酸抑制作用。慢性治疗后基础血清胃泌素水平略有升高，但具有显著性。
