Fritsch W P, Scholten T, Müller J, Hengels K J, Hanrath K D
Scand J Gastroenterol Suppl. 1982;72:173-7.
50 mg pirenzepine inhibit basal acid secretion by 39.9% and peptone-stimulated acid output by 21.3%. The percentage of inhibition is nearly doubled if the same dose is given after a treatment with 50 mg pirenzepine twice daily for 3 to 7 days. No acute effect on serum gastrin levels can be demonstrated by a single dose of pirenzepine. After pretreatment only a small increase of basal gastrin levels is observed, serum gastrin does not change during stimulation. On the bases of these results the effect on ulcer healing by high doses of pirenzepine is probably due to a much more pronounced acid inhibition. One reason for stronger inhibition of acid secretion after pretreatment with pirenzepine is probably accumulation of the drug, other reasons may be distribution space or receptor binding. The effect of anticholinergic drugs on serum gastrin concentrations is probably dose-dependent.
50毫克哌仑西平可抑制基础胃酸分泌39.9%，抑制蛋白胨刺激的胃酸分泌21.3%。若在每日两次服用50毫克哌仑西平，连续治疗3至7天后给予相同剂量，则抑制百分比几乎翻倍。单次服用哌仑西平对血清胃泌素水平无急性影响。预处理后仅观察到基础胃泌素水平略有升高，刺激期间血清胃泌素无变化。基于这些结果，高剂量哌仑西平对溃疡愈合的作用可能是由于更显著的胃酸抑制。哌仑西平预处理后胃酸分泌抑制作用增强的一个原因可能是药物蓄积，其他原因可能是分布容积或受体结合。抗胆碱能药物对血清胃泌素浓度的影响可能取决于剂量。
