[Serum antibody and splenocyte immunoglobulin receptor affinity in multiply immunized mice].

In the process of repeated immunization of CBA mice with soluble Pasteurella pestis capsular antigen the concentration of antibodies in the blood increased, but the dynamics of antibody affinity in the serum did not correlate with this process. For the first time the average splenocyte receptor affinity was measured, and this characteristics was found to exceed that of the corresponding serum antibodies. To explain the heterogeneity of antibodies, two hypotheses have been proposed. One hypothesis states that the heterogeneity of antibodies is determined by the cyclic character of antigen concentration at the site of injection, while according to the other hypothesis, it is determined by the interaction of immunoglobulins of different idiotypes with idiotypic antibodies.