Levi M I, Livshits M M
Zh Mikrobiol Epidemiol Immunobiol. 1981 Jun(6):80-5.
In the process of repeated immunization of CBA mice with soluble Pasteurella pestis capsular antigen the concentration of antibodies in the blood increased, but the dynamics of antibody affinity in the serum did not correlate with this process. For the first time the average splenocyte receptor affinity was measured, and this characteristics was found to exceed that of the corresponding serum antibodies. To explain the heterogeneity of antibodies, two hypotheses have been proposed. One hypothesis states that the heterogeneity of antibodies is determined by the cyclic character of antigen concentration at the site of injection, while according to the other hypothesis, it is determined by the interaction of immunoglobulins of different idiotypes with idiotypic antibodies.
在用可溶性鼠疫巴氏杆菌荚膜抗原反复免疫CBA小鼠的过程中，血液中抗体浓度升高，但血清中抗体亲和力的动态变化与这一过程无关。首次测量了平均脾细胞受体亲和力，发现这一特性超过了相应血清抗体的亲和力。为了解释抗体的异质性，提出了两种假说。一种假说认为，抗体的异质性由注射部位抗原浓度的周期性特征决定，而另一种假说则认为，它由不同独特型的免疫球蛋白与独特型抗体的相互作用决定。
