[单克隆抗体亲和力的异质性]
[Heterogeneity of monoclonal antibody affinity].
作者信息
Levi M I
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 1985 Mar(3):67-74.
PMID:3838847
Abstract
In experiments with Pasteurella pestis monovalent capsular antigen and hybridoma monoclonal antibodies obtained after cloning and recloning the heterogeneity of the active centers of antibodies with respect to their affinity was revealed. In ascitic fluids obtained from the animals inoculated with different hybridoma clones 5 groups of antibodies, differing in their affinity, were determined in each fluid sample.
摘要
在用鼠疫耶尔森氏菌单价荚膜抗原以及通过克隆和再克隆获得的杂交瘤单克隆抗体进行的实验中，揭示了抗体活性中心在亲和力方面的异质性。在从接种了不同杂交瘤克隆的动物获得的腹水样本中，每组样本均检测到5组亲和力不同的抗体。
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