Abouleish E, Barmada M A, Nemoto E M, Tung A, Winter P
Br J Anaesth. 1981 Oct;53(10):1027-32. doi: 10.1093/bja/53.10.1027.
In a double-blind study, seven Macaca fascicularis monkeys receiving intrathecal (i.t.) morphine in saline, 0.07 mg kg-1, were compared with a control group of four monkeys receiving either lumbar puncture alone (n = 1) or i.t. saline (n = 3). Neither morphine nor saline solutions contained preservatives. Arterial blood gas tensions, respiration, arterial pressure, e.c.g., state of consciousness and motor function were recorded for 24 h. The control group was sacrificed 42 days later and the study group was sacrificed at 6 (n = 2) or 42 days (n = 5) after injection. The central nervous system, meninges, nerve roots and dorsal root ganglia were examined macroscopically and microscopically. Respiratory depression did not occur in either the control or the study groups. There were moderate but statistically significant decreases in systolic and diastolic arterial pressures following i.t. morphine. In both groups, the pathological findings were localized to the cauda equina region and characterized by mononuclear cell infiltration. In neither group was there evidence of demyelination, arachnoiditis or necrosis. Focal endoneurial fibrosis was found in only one animal in the control group following multiple lumbar punctures associated with paraesthesia. The features appeared to correlate with the physical trauma associated with lumbar puncture rather than with the injectate.
在一项双盲研究中，将7只接受鞘内注射（i.t.）0.07 mg/kg生理盐水吗啡的食蟹猴与一个对照组的4只猴子进行比较，对照组的猴子要么仅接受腰椎穿刺（n = 1），要么接受鞘内注射生理盐水（n = 3）。吗啡溶液和生理盐水溶液均不含防腐剂。记录24小时内的动脉血气张力、呼吸、动脉压、心电图、意识状态和运动功能。对照组在42天后处死，研究组在注射后6天（n = 2）或42天（n = 5）处死。对中枢神经系统、脑膜、神经根和背根神经节进行宏观和微观检查。对照组和研究组均未出现呼吸抑制。鞘内注射吗啡后，收缩压和舒张压出现中度但具有统计学意义的下降。在两组中，病理结果均局限于马尾区域，其特征为单核细胞浸润。两组均未发现脱髓鞘、蛛网膜炎或坏死的证据。在对照组中，仅1只动物在多次腰椎穿刺并伴有感觉异常后出现局灶性神经内膜纤维化。这些特征似乎与腰椎穿刺相关的物理创伤有关，而非与注射剂有关。
