Goerke J, Gonzales J
J Appl Physiol Respir Environ Exerc Physiol. 1981 Nov;51(5):1108-14. doi: 10.1152/jappl.1981.51.5.1108.
Dipalmitoyl phosphatidylcholine is the principal component of lung surfactant, and knowledge of its behavior as a film spread at the air-water interface is essential for understanding how lung surfactant itself works. We therefore studied the collapse rates of very low surface tension air-water monolayers of dipalmitoyl, dimyristoyl, and palmitoyl-myristoyl phosphatidylcholines at different temperatures. In each case we found that the monolayers abruptly became unstable at temperature 3-4 degree C above their bulk lipid-water phase transition temperatures (Tc). This accords with a comparable increase in Tc occurring in bulk systems subjected to high pressure. These findings are also consistent with the behavior of isolated rat lungs, which have been found to require higher transmural pressures to maintain a given volume on deflation when kept at temperature above the Tc of dipalmitoyl phosphatidylcholine.
二棕榈酰磷脂酰胆碱是肺表面活性剂的主要成分，了解其在气-水界面铺展成膜的行为对于理解肺表面活性剂本身的工作原理至关重要。因此，我们研究了二棕榈酰、二肉豆蔻酰和棕榈酰-肉豆蔻酰磷脂酰胆碱在不同温度下极低表面张力的气-水单层膜的崩塌速率。在每种情况下，我们发现单层膜在高于其本体脂质-水相转变温度（Tc）3-4摄氏度时会突然变得不稳定。这与在高压下的本体系统中Tc的类似升高相一致。这些发现也与离体大鼠肺的行为一致，已发现当保持在高于二棕榈酰磷脂酰胆碱Tc的温度时，离体大鼠肺在放气时需要更高的跨壁压力来维持给定的体积。
