Murty J S, Rao P H
Mutat Res. 1981 Sep;83(2):221-32. doi: 10.1016/0027-5107(81)90007-5.
The nature of the probability distribution of post-implantation dominant lethality was investigated in terms of the distribution of dead implants per female. It has been postulated that this distribution would be poisson in a control series of females but may follow a compound or a contagious distribution such as the beta binomial, negative binomial or Neyman type A in the treated series of females. The nature of these compound distributions for fitting mammalian mutagenicity has been examined. The implications of the results on the estimation of induced mutation rates are discussed.
根据每只雌性动物体内死亡植入物的分布情况，对植入后显性致死率的概率分布性质进行了研究。据推测，在雌性动物的对照组中，这种分布符合泊松分布，但在经处理的雌性动物组中，可能遵循复合分布或传染性分布，如β二项分布、负二项分布或奈曼A分布。已对这些用于拟合哺乳动物致突变性的复合分布的性质进行了研究。并讨论了这些结果对诱导突变率估计的影响。
