过敏反应慢反应物质拮抗剂FPL 55712增强离体气道对支气管收缩激动剂的反应

Enhancement of isolated airway responses to bronchoconstrictive agonists by the slow-reacting substance of anaphylaxis antagonist FPL 55712.

作者信息

Krell R D, Osborn R, Falcone K, Vickery L

出版信息

Prostaglandins. 1981 Sep;22(3):423-32. doi: 10.1016/0090-6980(81)90103-9.

DOI:10.1016/0090-6980(81)90103-9

Abstract

The activity of the SRS-A antagonist FPL 55712 against histamine, carbachol and ion-induced contraction of isolated airway smooth muscle was evaluated. FPL 55712 enhanced responses of guinea-pig trachea and parenchymal lung strips to histamine and carbachol. Enhancement was not obviously related to concentration. It is suggested that this effect may be the result of cyclo-oxygenase inhibition by FPL 55712. These observations may account for some of the anomalous findings regarding the antagonism of leukotrienes by FPL 55712 previously reported.

摘要

评估了SRS - A拮抗剂FPL 55712对组胺、卡巴胆碱和离子诱导的离体气道平滑肌收缩的活性。FPL 55712增强了豚鼠气管和肺实质条带对组胺和卡巴胆碱的反应。增强作用与浓度无明显相关性。提示这种效应可能是FPL 55712抑制环氧化酶的结果。这些观察结果可能解释了先前报道的关于FPL 55712对白三烯拮抗作用的一些异常发现。

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Enhancement of isolated airway responses to bronchoconstrictive agonists by the slow-reacting substance of anaphylaxis antagonist FPL 55712.过敏反应慢反应物质拮抗剂FPL 55712增强离体气道对支气管收缩激动剂的反应

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Effect of inhibition of synthesis and receptor antagonism of SRS-A in cardiac anaphylaxis.SRS-A合成抑制及受体拮抗在心脏过敏反应中的作用

Br J Pharmacol. 1983 Sep;80(1):73-80. doi: 10.1111/j.1476-5381.1983.tb11051.x.

2

Alteration of drug responsiveness in guinea-pig lung anaphylaxis using different antigen challenge concentrations.使用不同抗原激发浓度时豚鼠肺过敏反应中药物反应性的改变。

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