过敏反应慢反应物质的部分纯化制剂对豚鼠气管螺旋条和实质条的不同作用。
Differential effects of a partially purified preparation of slow-reacting substance of anaphylaxis on guinea pig tracheal spirals and parenchymal strips.
作者信息
Drazen J M, Lewis R A, Wasserman S I, Orange R P, Austen K F
出版信息
J Clin Invest. 1979 Jan;63(1):1-5. doi: 10.1172/JCI109262.
Abstract
The contractile effects of partially purified slow-reacting substance of anaphylaxis (SRS-A) and histamine were compared on isolated guinea pig tracheal spirals and parenchymal strips. Histamine was equally active on both isolated tissues in a concentration-related fashion. SRS-A (0.1--10.0 U/ml) produced a concentration-related effect on parenchymal strips, whereas the tracheal spiral was 100 times less sensitive to this mediator. The contractile activity of SRS-A on parenchymal strips was diminished by incubation with limpet arylsulfatase and antagonized by FPL 55712, a known SRS-A antagonist. SRS-A, further purified by high pressure liquid chromatography, also demonstrated this preferential activity on guinea pig parenchymal strips. These data are consistent with the hypothesis, based on previous in vivo observations, that SRS-A is a selective peripheral airway constrictor.
摘要
在离体豚鼠气管螺旋条和实质条上比较了部分纯化的过敏反应慢反应物质（SRS-A）和组胺的收缩效应。组胺在两种离体组织上均呈浓度依赖性地同等活跃。SRS-A（0.1 - 10.0 U/ml）对实质条产生浓度依赖性效应，而气管螺旋条对该介质的敏感性低100倍。与帽贝芳基硫酸酯酶孵育后，SRS-A对实质条的收缩活性降低，并被已知的SRS-A拮抗剂FPL 55712拮抗。经高压液相色谱进一步纯化的SRS-A在豚鼠实质条上也表现出这种优先活性。这些数据与基于先前体内观察结果的假设一致，即SRS-A是一种选择性外周气道收缩剂。
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