用³H 1,25（OH）₂维生素D₂和³H 25（OH）维生素D₃对大鼠甲状旁腺进行放射自显影研究。
Autoradiographic studies with 3H 1,25 (OH)2 vitamin D2 and 3H 25 (OH) vitamin D3 in rat parathyroid glands.
作者信息
Stumpf W E, Sar M, Reid F A, Huang S, Narbaitz R, DeLuca H F
出版信息
Cell Tissue Res. 1981;221(2):333-8. doi: 10.1007/BF00216737.
After injection of radiolabeled 1,35 (OH)s vitamin D3, nuclear concentration of radioactivity is observed in parenchymal cells o hte parathyroid gland in pregnant, adult male, and 10-day male neonatal rats. In competition studies with unlabeled 1,25 (OH)2 vitamin D3, but not with 25 (OH) vitamin D3, in contrast to 3H 1,25 (OH)2 vitamin D3, do not show nuclear concentration in cells of te parathyroid. The results of te autoradiographic studies suggest the presence of receptors for a direct effect of 1,35 (OH)2 vitamin D3 on the parathyroid gland for modulation of parathyroid hormone secretion.
注射放射性标记的1,35（OH）₂维生素D₃后，在怀孕大鼠、成年雄性大鼠和10日龄雄性新生大鼠的甲状旁腺实质细胞中观察到放射性的核内聚集。在与未标记的1,25（OH）₂维生素D₃的竞争研究中，但不是与25（OH）维生素D₃的竞争研究中，与³H 1,25（OH）₂维生素D₃相反，甲状旁腺细胞中未显示核内聚集。放射自显影研究结果表明存在1,35（OH）₂维生素D₃对甲状旁腺直接作用以调节甲状旁腺激素分泌的受体。
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