某些羟基化维生素D代谢产物对体外培养的大鼠分散甲状旁腺细胞甲状旁腺素分泌的比较作用。

Comparative effects of some hydroxylated vitamin D metabolites on parathyrin secretion by dispersed rat parathyroid cells in vitro.

作者信息

Gruson M, Demignon J, Del Pino Montes J, Miravet L

出版信息

Steroids. 1982 Sep;40(3):275-85. doi: 10.1016/0039-128x(82)90040-x.

Abstract

We have previously discussed the action of 1 alpha,25-(OH)2D3, (24R) 24,25-(OH)2 D3 and (25S) 25,26-(OH)2D3 on parathyrin secretion by isolated rat parathyroid cells. In this work, we have compared these effects with those obtained with 1 alpha-OH D3, 25-OH D3 and 1 alpha-OH D2. In decreasing order, the activities were: 1 alpha,25-(OH)2D3 greater than 1 alpha-OH D3 greater than (24R) 24,25-(OH)2D3 greater than 25-OH D3 greater than (25S) 25,26(OH)2D3 greater than 1 alpha-OH D2. The presence of two hydroxyl groups with one hydroxyl group in alpha position seems to have the higher activity to inhibit the parathyroid secretion. At least, the nature of the side chain conformation also plays a part upon the effect of PTH release.

摘要

我们之前已经讨论过1α,25-(OH)₂D₃、(24R) 24,25-(OH)₂D₃和(25S) 25,26-(OH)₂D₃对分离的大鼠甲状旁腺细胞甲状旁腺素分泌的作用。在这项工作中，我们将这些效应与用1α-OH D₃、25-OH D₃和1α-OH D₂所获得的效应进行了比较。按活性递减顺序排列为：1α,25-(OH)₂D₃＞1α-OH D₃＞(24R) 24,25-(OH)₂D₃＞25-OH D₃＞(25S) 25,26-(OH)₂D₃＞1α-OH D₂。在α位带有一个羟基的两个羟基的存在似乎对抑制甲状旁腺分泌具有更高的活性。至少，侧链构象的性质对甲状旁腺素释放的效应也有影响。