Yamamoto M, Saito S, Sakurada T, Kaise K, Kaise N, Yoshida K, Kitaoka H, Fukazawa H, Yoshinaga K
Tohoku J Exp Med. 1981 Nov;135(3):323-30. doi: 10.1620/tjem.135.323.
Iodine content, protein content and percentage of thyroglobulin to total protein in the thyroid glands were studied in two groups of 10 patients with Hashimoto's thyroiditis (5 euthyroid and 5 hypothyroid patients) and in 6 normal subject. Iodine content was significantly decreased in both hypothyroid (24 +/- 29 microgram/g wet weight of thyroid tissue, mean +/- S.D., p less than 0.01) and euthyroid (96 +/- 52, p less than 0.01) groups of Hashimoto's thyroiditis compared with those in controls (779 +/- 37). The value of hypothyroid group was significantly smaller than that of euthyroid group (p less than 0.05). A significant negative correlation was obtained between thyroidal iodine content and serum TSH (r = -0.68, y = -0.41 chi + 55.6, p less than 0.05). Thyroidal protein and percentage of thyroglobulin to total thyroidal protein were also decreased in Hashimoto's thyroiditis compared with controls, while there was no difference between euthyroid and hypothyroid groups in these values. The percentage of thyroglobulin-bound 131I obtained by in vitro iodination of thyroglobulin in Hashimoto's thyroiditis appeared to be decreased in 2 cases of hypothyroid group. Some immunological reaction occurring in Hashimoto's thyroiditis may change the structure of thyroglobulin and in turn the normal iodination of thyroglobulin may be disturbed.
对两组各10例桥本甲状腺炎患者（5例甲状腺功能正常和5例甲状腺功能减退患者）以及6例正常受试者的甲状腺碘含量、蛋白质含量和甲状腺球蛋白占总蛋白的百分比进行了研究。与对照组（779±37）相比，桥本甲状腺炎甲状腺功能减退组（甲状腺组织湿重中碘含量为24±29微克/克，均值±标准差，p<0.01）和甲状腺功能正常组（96±52，p<0.01）的碘含量均显著降低。甲状腺功能减退组的值显著低于甲状腺功能正常组（p<0.05）。甲状腺碘含量与血清促甲状腺激素之间存在显著负相关（r = -0.68，y = -0.41χ + 55.6，p<0.05）。与对照组相比，桥本甲状腺炎患者的甲状腺蛋白及甲状腺球蛋白占总甲状腺蛋白的百分比也降低，而甲状腺功能正常组和甲状腺功能减退组在这些值上无差异。在桥本甲状腺炎患者中，通过甲状腺球蛋白体外碘化获得的甲状腺球蛋白结合131I的百分比在2例甲状腺功能减退组患者中似乎降低。桥本甲状腺炎中发生的一些免疫反应可能会改变甲状腺球蛋白的结构，进而可能干扰甲状腺球蛋白的正常碘化。
